REDUCED HIP CORTICAL POROSITY WITH DENOSUMAB (DMAB) TREATMENT IN WOMEN WITH OSTEOPOROSIS

Abstract

Background Cortical mass and structure (i.e., porosity, thickness, area) influence bone strength, and contribute to nonvertebral fracture risk. Cortical porosity, a reflection of the degree of structural decay associated with exponential worsening of bone fragility, is the result of unbalanced and accelerated intracortical remodeling causing canals to enlarge and coalesce thereby fragmenting the cortex. While reducing remodeling will limit worsening of porosity, reversing porosity should be considered for individuals already at increased risk of fracture. We previously reported that hip cortical mass and thickness improved over 3 years of DMAb administration, which could be explained by infi..