Journal article

The therapy 'pill': Achieving treatment dose within a rehabilitation trial

Janice M Collier, Julie Bernhardt



Background: Developing high quality clinical trials within rehabilitation research is achievable and should be pursued wherever possible. One of the greatest challenges rehabilitation trialists face is defining experimental and control interventions and ensuring that the intervention dose is delivered as planned. Aim: We describe procedures employed within a pilot randomised controlled trial of a rehabilitation intervention to monitor therapy dose. Method: The trial setting was two acute stroke units in large teaching hospitals in Melbourne, Australia. The design was a randomised controlled trial of very early mobilisation (commenced within 24 hours of stroke onset) plus standard care (VEM) ..

View full abstract


Awarded by National Heart Foundation of Australia

Awarded by National Health and Medical Research Council (Australia)

Funding Acknowledgements

We appreciate the participation and support of survivors and their carers in this study. We gratefully acknowledge assistance from the following people:Austin Hospital: Tara Sharpley, Mark Hindson, Lia AugoustakisSt. Vincent's Hospital: Kim Brock, Bernadette Dornom, Carolyn Luke, Paul IlettNational Stroke Research Institute: Clara Fu, Marcus Nicol.This trial was supported by grants from the National Heart Foundation of Australia (Grant Number G 04M 1571), Affinity Health and an equipment grant from the Austin Health Medical Research Fund. Dr Bernhardt was supported by a National Health and Medical Research Council (Australia) fellowship (157305).