Journal article

Metabolic profiling reveals anomalous energy metabolism and oxidative stress pathways in chronic fatigue syndrome patients

Christopher W Armstrong, Neil R McGregor, Donald P Lewis, Henry L Butt, Paul R Gooley

METABOLOMICS | SPRINGER | Published : 2015


Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating long-term multisystem disorder with a central and inexplicably persistent fatigue symptom that is unable to be relieved by rest. Energy metabolism and oxidative stress have been recent focal points of ME/CFS research and in this study we were able to elucidate metabolic pathways that were indicative of their dysfunction. Blood and urine samples were collected from 34 females with ME/CFS (34.9 ± 1.8 SE years old) and 25 non-ME/CFS female participants (33.0 ± 1.6 SE years old). All samples underwent metabolic profiling via 1D H Nuclear magnetic resonance spectroscopy and quantitated metabolites were assessed for sig..

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Funding Acknowledgements

The authors of this work would like to thank the nursing and administrative staff at the CFS Discovery clinic for their important help throughout this study. This work was supported by grants from the Judith Jane Mason & Harold Stannett Williams Memorial Foundation (The Mason Foundation) and equipment grants from the Rowden White foundation and State of Victoria.