Journal article

Dissecting the antibody constant region protective immune parameters in HIV infection

Amy W Chung, Galit Alter



RV144 vaccine immune-correlates analysis has generated a renewed interest in understanding the potentially protective role of non-neutralizing antibodies in HIV infection and vaccine design. Antibodies consist of a variable region involved in antigen binding and a constant region. While both ends of the antibody collaborate to induce protective immunity, it is through the constant portion that an antibody provides instructions to the innate immune system on how the recognized antigen should be processed, contributing directly to antiviral immunity. Antibody constant regions, despite their name, are not uniform structures, but can vary both in protein sequence and glycosylation, together modu..

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University of Melbourne Researchers


Awarded by Bill and Melinda Gates Collaboration for AIDS Vaccine Discovery

Awarded by National Health and Medical Research Center

Funding Acknowledgements

This work was supported by: the Bill and Melinda Gates Collaboration for AIDS Vaccine Discovery (OPP1032817: Leveraging Antibody Effector Function); NIH1R01AI102660-02 and 5R01Al080289-03 to G Alter; and National Health and Medical Research Center (APP1036470) and Massachusetts General Hospital Executive Committee on Research Fund for Medical Discovery Fellowship to AW Chung. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.