Feasibility and stability of metaraminol in pre-filled syringes

Abstract

Background:Meta raminollO mg/mL injection i s often diluted with sodium chlorid e 0.9% and pre-drawn intosy ringes by a n aesthctists for use in the management of intraoperative hypotensive crisis. The 10 mg/mL ampoule presentation poses a significant safety hazard since the entil'e content needs to be drawn into a syringe and then diluted so that 0.5 mgdoses may bead ministered. There have been incidents where 10 mgrather than the intended 0.5 mghave been administered to the patient. Additionally the pre-drawn m etaraminol is discarded at the end of the case if not used, whid1 resultsinsi gnificru1t wastage. A pre-filled syringe presentation of metaraminol wi ll improve patient safety and r..