Journal article
Global circulation patterns of seasonal influenza viruses vary with antigenic drift
T Bedford, S Riley, IG Barr, S Broor, M Chadha, NJ Cox, RS Daniels, CP Gunasekaran, AC Hurt, A Kelso, A Klimov, NS Lewis, X Li, JW McCauley, T Odagiri, V Potdar, A Rambaut, Y Shu, E Skepner, DJ Smith Show all
Nature | Published : 2015
DOI: 10.1038/nature14460
Abstract
Understanding the spatiotemporal patterns of emergence and circulation of new human seasonal influenza virus variants is a key scientific and public health challenge. The global circulation patterns of influenza A/H3N2 viruses are well characterized, but the patterns of A/H1N1 and B viruses have remained largely unexplored. Here we show that the global circulation patterns of A/H1N1 (up to 2009), B/Victoria, and B/Yamagata viruses differ substantially from those of A/H3N2 viruses, on the basis of analyses of 9,604 haemagglutinin sequences of human seasonal influenza viruses from 2000 to 2012. Whereas genetic variants of A/H3N2 viruses did not persist locally between epidemics and were reseed..
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Awarded by Department of Health, Australian Government
Funding Acknowledgements
We thank National Influenza Centres worldwide for their contributions to influenza virus surveillance. T.B. was supported by a Newton International Fellowship from the Royal Society and through National Institutes of Health (NIH) U54 GM111274. S.R. was supported by Medical Research Council (UK, Project MR/J008761/1), Wellcome Trust (UK, Project 093488/Z/10/Z), Fogarty International Centre (USA, R01 TW008246-01), Department of Homeland Security (USA, RAPIDD program), National Institute of General Medical Sciences (USA, MIDAS U01 GM110721-01) and National Institute for Health Research (UK, Health Protection Research Unit funding). The Melbourne WHO Collaborating Centre for Reference and Research on Influenza was supported by the Australian Government Department of Health and thanks N. Komadina and Y.-M. Deng. The Atlanta WHO Collaborating Center for Surveillance, Epidemiology and Control of Influenza was supported by the US Department of Health and Human Services. NIV thanks A.C. Mishra, M. Chawla-Sarkar, A. M. Abraham, D. Biswas, S. Shrikhande, B. AnuKumar, and A. Jain. Influenza surveillance in India was expanded, in part, through US Cooperative Agreements (5U50C1024407 and U51IP000333) and by the Indian Council of Medical Research. M. A. S. was supported through National Science Foundation DMS 1264153 and NIH R01 AI 107034. Work of the WHO Collaborating Centre for Reference and Research on Influenza at the MRC National Institute for Medical Research was supported by U117512723. P.L., A.R. & M.A.S were supported by EU Seventh Framework Programme [FP7/2007-2013] under Grant Agreement no. 278433-PREDEMICS and ERC Grant agreement no. 260864. C.A.R. was supported by a University Research Fellowship from the Royal Society.