Journal article
Reduced IL-17A secretion is associated with high levels of pneumococcal nasopharyngeal carriage in Fijian children
E Hoe, LK Boelsen, ZQ Toh, GW Sun, GC Koo, A Balloch, R Marimla, EM Dunne, L Tikoduadua, FM Russell, C Satzke, EK Mulholland, PV Licciardi
Plos One | PUBLIC LIBRARY SCIENCE | Published : 2015
Abstract
Streptococcus pneumonia (the pneumococcus) is the leading vaccine preventable cause of serious infections in infants under 5 years of age. The major correlate of protection for pneumococcal infections is serotype-specific IgG antibody. More recently, antibody-independent mechanisms of protection have also been identified. Preclinical studies have found that IL-17 secreting CD4+ Th17 cells in reducing pneumococcal colonisation. This study assessed IL-17A levels in children from Fiji with high and low pneumococcal carriage density, as measured by quantitative real-time PCR (qPCR). We studied Th17 responses in 54 children who were designated as high density carriers (N=27, >8.21×105 CFU/ml) or ..
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Awarded by National Institute of Allergy and Infectious Diseases
Funding Acknowledgements
The study was funded by National Institute of Allergy Infectious Diseases (Grant number: 1R01AI085198-01A1). This study was supported in part by the Victorian Government's Operational Infrastructure Support Program. Paul V. Licciardi is the recipient of a National Health and Medical Research Council (NHMRC) Early Career Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.