Reduced IL-17A Secretion Is Associated with High Levels of Pneumococcal Nasopharyngeal Carriage in Fijian Children
Edwin Hoe, Laura K Boelsen, Zheng Quan Toh, Guang Wen Sun, Ghee Chong Koo, Anne Balloch, Rachel Marimla, Eileen M Dunne, Lisi Tikoduadua, Fiona M Russell, Catherine Satzke, E Kim Mulholland, Paul V Licciardi
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
Streptococcus pneumonia (the pneumococcus) is the leading vaccine preventable cause of serious infections in infants under 5 years of age. The major correlate of protection for pneumococcal infections is serotype-specific IgG antibody. More recently, antibody-independent mechanisms of protection have also been identified. Preclinical studies have found that IL-17 secreting CD4+ Th17 cells in reducing pneumococcal colonisation. This study assessed IL-17A levels in children from Fiji with high and low pneumococcal carriage density, as measured by quantitative real-time PCR (qPCR). We studied Th17 responses in 54 children who were designated as high density carriers (N=27, >8.21x10(5) CFU/ml) o..View full abstract
Awarded by National Institute of Allergy Infectious Diseases
Awarded by NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
The study was funded by National Institute of Allergy Infectious Diseases (Grant number: 1R01AI085198-01A1). This study was supported in part by the Victorian Government's Operational Infrastructure Support Program. Paul V. Licciardi is the recipient of a National Health and Medical Research Council (NHMRC) Early Career Fellowship. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.