Journal article

Comparative analysis of hepatic ethanol metabolism in Fawn-Hooded and Wistar-Kyoto rats

DJ Lodge, AJ Lawrence

ALCOHOL | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2003

Abstract

Results of a number of studies have supported the suggestion that a correlation exists between voluntary ethanol consumption and enhanced ethanol metabolism in some (but not all) rodent strains. However, as yet, the capacity for alcohol-preferring Fawn-Hooded (FH) rats to metabolize ethanol has not been investigated. Hence, the aim of the current study was to compare the activities of the major hepatic enzymes involved in ethanol metabolism--cytosolic alcohol dehydrogenase (ADH) and mitochondrial aldehyde dehydrogenase (ALDH)--in the FH rat and its alcohol-nonpreferring counterpart, the Wistar-Kyoto (WKY) rat. In addition, the effect of chronic (5 weeks in vivo) ethanol pretreatment on the a..

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