Journal article

Comparative analysis of the central CCK system in Fawn Hooded and Wister Kyoto rats: extended localisation of CCK-A receptors throughout the rat brain using a novel radioligand

DJ Lodge, AJ Lawrence

REGULATORY PEPTIDES | ELSEVIER SCIENCE BV | Published : 2001

Abstract

The neuropeptide cholecystokinin has been implicated in the actions of a number of central processes including anxiety and reward. For this reason, the aim of the present study was to compare the density of CCK-A and -B receptors and the mRNA encoding preproCCK throughout the brains of an alcohol-preferring (Fawn Hooded) rat strain with that of a non-alcohol-preferring (Wistar Kyoto) strain of rat. Our study revealed significant differences with regard to the central CCK system of the FH compared to the WKY rat, including differences in CCK-A receptor binding throughout the dorsal medulla, and altered CCK-B binding density throughout the cerebral cortex and reticular nucleus of the thalamus...

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