Journal article

[I-125]-galanin binding sites in the human nodose ganglion

BW Sweerts, B Jarrott, AJ Lawrence

LIFE SCIENCES | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2000

Abstract

The cell bodies of centrally-projecting vagal afferent neurons are contained in the inferior vagal (nodose) ganglion. Although binding sites for a number of different neuropeptides/modulators have been detected in the human nodose ganglion, the presence of galanin binding sites has not been reported. In vitro receptor autoradiography using [125I]-galanin enabled visualisation of binding sites for galanin in the human nodose ganglion. The presence of such binding sites suggests a potential role for galanin in the neuromodulation of vagal transmission in humans.