5-HT transporter sites and 5-HT(1A) and 5-HT3 receptors in fawn-hooded rats: A quantitative autoradiography study

Abstract

Background: The neuroanatomical profiles of 5-HT(1A) receptors, 5-HT3 receptors, and 5-HT transporters (5-HTT) in the brain of the Fawn-Hooded (FH) rat, particularly mesocorticolimbic regions, are not fully elucidated. Methods: By means of in vitro quantitative autoradiography, we used [3H]citalopram, [3H]8-OH-DPAT, and [3H]GR65630 to label 5-HTT, 5-HT(1A) receptors, and 5-HT3 receptors in the brain of alcohol-naive FH rats, Wistar-Kyoto (WKY) rats, and FH rats given free access to 5% ethanol and/or after 24 to 48 hr withdrawal. Results and Conclusions: In alcohol-naive rats, FH rats displayed significantly higher (p < 0.05) densities of [3H]citalopram binding in the nucleus accumbens (+30%)..