Journal article

L-GLUTAMATE AS A NEUROTRANSMITTER AT BARORECEPTOR AFFERENTS - EVIDENCE FROM IN-VIVO MICRODIALYSIS

AJ LAWRENCE, B JARROTT

NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 1994

Abstract

In vivo microdialysis was employed to measure release of endogenous L-glutamate and L-aspartate in the region of the dorsomedial medulla oblongata including the medial nucleus tractus solitarius of the anaesthetized rat. Basal extracellular levels of these amino acids were stable and increased over two-fold when the perfusate was changed to a high KCl (80 mM) artificial cerebrospinal fluid. This high K(+)-evoked release was calcium-dependent, while basal levels were insensitive to removal of calcium ions from the perfusate. An intravenous infusion of phenylephrine, which elevated blood pressure, caused a marked increase of both spontaneous and evoked release of glutamate. In contrast asparta..

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