Journal article
Leukemia inhibitory factor is an autocrine survival factor for Schwann cells
BJ Dowsing, WA Morrison, NA Nicola, GP Starkey, T Bucci, TJ Kilpatrick
JOURNAL OF NEUROCHEMISTRY | WILEY | Published : 1999
Abstract
Schwann cells play a major role in promoting nerve survival and regeneration after injury. Their activities include providing neurotrophic factors and increasing the production of extracellular matrix components and cell surface adhesion molecules to promote axon regeneration. Following nerve transection, leukemia inhibitory factor (LIF) is up-regulated by Schwann cells at the injury site. LIF receptors are also up-regulated at the nerve injury site, but their cellular localization and function have not been fully characterized. We demonstrate that Schwann cells express mRNAs for LIF and the LIF receptor components LIF receptor subunit beta and glycoprotein 130 in vitro. We also show that al..
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