Journal article

LEUKEMIA INHIBITORY FACTOR PROMOTES THE NEURONAL DEVELOPMENT OF SPINAL-CORD PRECURSORS FROM THE NEURAL-TUBE

LJ RICHARDS, TJ KILPATRICK, PF BARTLETT, M MURPHY

JOURNAL OF NEUROSCIENCE RESEARCH | WILEY-LISS | Published : 1992

Abstract

Recent evidence from our laboratory has shown that leukemia inhibitory factor (LIF) can act early in peripheral nervous system development. We have investigated a potential role of LIF in the developing spinal cord. In explants and dissociated cultures of spinal cord primordium, LIF stimulated a profuse neurite outgrowth. To determine if these effects were related to neuronal differentiation, cells were plated at low cell density and stained for neurofilament. LIF stimulated an increase in the number of newly differentiated neurons, without inducing proliferation of the precursors. Given that LIF has previously reported effects as a cholinergic switching factor for sympathetic neurons, we in..

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