Journal article

Breaking up of prolonged sitting over three days sustains, but does not enhance, lowering of postprandial plasma glucose and insulin in overweight and obese adults

Robyn N Larsen, Bronwyn A Kingwell, Carol Robinson, Louise Hammond, Ester Cerin, Jonathan E Shaw, Genevieve N Healy, Marc T Hamilton, Neville Owen, David W Dunstan

CLINICAL SCIENCE | PORTLAND PRESS LTD | Published : 2015

Abstract

To compare the cumulative (3-day) effect of prolonged sitting on metabolic responses during a mixed meal tolerance test (MTT), with sitting that is regularly interrupted with brief bouts of light-intensity walking. Overweight/obese adults (n=19) were recruited for a randomized, 3-day, outpatient, cross-over trial involving: (1) 7-h days of uninterrupted sitting (SIT); and (2) 7-h days of sitting with light-intensity activity breaks [BREAKS; 2-min of treadmill walking (3.2 km/h) every 20 min (total: 17 breaks/day)]. On days 1 and 3, participants underwent a MTT (75 g of carbohydrate, 50 g of fat) and the incremental area under the curve (iAUC) was calculated from hourly blood samples. General..

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Grants

Awarded by National Health and Medical Research Council


Awarded by Australian Research Council Future Research Fellowship


Awarded by Australian Heart Foundation


Awarded by NHMRC Centre of Research Excellence Grant


Funding Acknowledgements

This work was supported by the National Health and Medical Research Council [grant numbers NHMRC #540107, NHMRC #569940, NHMRC #1099454 (to B.A.K.), NHMRC #586623 (to J.E.S.) and NHMRC #1003960 (to N.O.)]; the Australian Research Council Future Research Fellowship [grant number FT100100918 (to D.W.D.)]; the Australian Heart Foundation [grant number #PH 12B 7054 (to G.N.H.)]; the Coca-Cola and the Edward G. Schleider Foundation (to M.T.H.); and the Victorian State Government and a NHMRC Centre of Research Excellence Grant [grant number NHMRC #1041056].