Journal article

Assessment of Macular Parameter Changes in Patients with Keratoconus Using Optical Coherence Tomography

Srujana Sahebjada, Fakir M Amirul Islam, Sanj Wickremasinghe, Mark Daniell, Paul N Baird



Keratoconus is typically diagnosed through changes at the anterior ocular surface. However, we wished to assess if macular parameter changes might also occur in these patients. We assessed posterior changes through the use of optical coherence tomography and compared to a nonkeratoconus patient group. All subjects underwent clinical examination including macular thickness measurements. The generalized estimation equation model was used to estimate the means and compare the differences in various measurements between keratoconus and nonkeratoconus patients. A total of 129 keratoconus eyes of 67 cases and 174 nonkeratoconus eyes of 87 controls were analysed. Keratoconus individuals presented w..

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Awarded by National Health and Medical Research Council (NHMRC) Clinical Research Excellence Grant

Awarded by NHMRC

Funding Acknowledgements

The authors wish to thank participants from the Keratoconus study who made this work possible. The authors would also like to thank the Eye Surgery Associates, Lindsay and Associates and Keratoconus Australia, and Mr. Tony Ngo for their assistance with recruitment. This project was funded by the National Health and Medical Research Council (NHMRC) Clinical Research Excellence Grant 529923, Translational Clinical Research in Major Eye Diseases, NHMRC Senior Research Fellowship 1028444 (PNB), Royal Victorian Eye and Ear Hospital Human Research Ethics Small Grants Committee, Lynn Quayle Charitable Trust Fund (managed by Equity Trustees), Lions Eye Donation Service, and the Angior Family Foundation. The Centre for Eye Research Australia (CERA) receives Operational Infrastructure Support from the Victorian Government.