Clinical implications of genomics for cancer risk genetics
David M Thomas, Paul A James, Mandy L Ballinger
LANCET ONCOLOGY | ELSEVIER SCIENCE INC | Published : 2015
The study of human genetics has provided substantial insight into cancer biology. With an increase in sequencing capacity and a reduction in sequencing costs, genomics will probably transform clinical cancer genetics. A heritable basis for many cancers is accepted, but so far less than half the genetic drivers have been identified. Genomics will increasingly be applied to populations irrespective of family history, which will change the framework of phenotype-directed genetic testing. Panel testing and whole genome sequencing will identify novel, polygenic, and de-novo determinants of cancer risk, often with lower penetrance, which will challenge present binary clinical classification system..View full abstract
Awarded by Australian National Health and Medical Research Council
Awarded by Cancer Australia grant
DMT is supported by the Australian National Health and Medical Research Council's Senior Research Fellowship (1003929). This work was supported in part by a Cancer Australia grant to DMT and MLB (1067094).