Journal article

Diabetic ketoacidosis and electroencephalographic changes in newly diagnosed pediatric patients

Mark T Mackay, Charlotte Molesworth, Elisabeth A Northam, Terrie E Inder, Fergus J Cameron



OBJECTIVE: To document electroencephalogram (EEG) changes and their correlation with clinical parameters in a newly diagnosed pediatric cohort of type 1 diabetes mellitus (T1DM) patients with and without diabetic ketoacidosis (DKA) and to define their medium term utility and significance. RESEARCH DESIGN AND METHODS: Prospective longitudinal study of children presenting with T1DM. EEGs were performed within 24 h of diagnosis, day 5, and at 6 months post-diagnosis and reviewed by a neurologist blinded to clinical status. Severity of encephalopathy was graded from 1 to 5 using the Aoki and Lombroso encephalopathy scale. Cognitive abilities were assessed using standardized tests of attention, m..

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Funding Acknowledgements

This research was supported by grants from the National Health and Medical Research Council of Australia and the Juvenile Diabetes Research Foundation. F. J. C. is the recipient of a grant from Scigen, and received payment for lectures and development of educational material from Novo Nordisk, Eli Lilly, Medtronic, and Abbott. M. T. M. has received honoraria from UCB Pharma, Jansen Cilag, and Sanofi-Aventis for presentations at industry-sponsored symposia. The authors also acknowledge the staff in the Department of Endocrinology and Diabetes, Royal Children's Hospital, for their assistance in completing this project, as well as the participating families who gave so generously of their time.