Journal article

Preterm fetal growth restriction is associated with increased parathyroid hormone-related protein expression in the fetal membranes

NE Curtis, RG King, JM Moseley, PWM Ho, GE Rice, ME Wlodek

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY | MOSBY, INC | Published : 2000

Abstract

OBJECTIVE: Parathyroid hormone-related protein has roles in normal fetal growth, placental calcium transport, and vascular tone regulation; these factors are compromised in growth-restricted fetuses. Our objective was to determine whether intrauterine parathyroid hormone-related protein expression was increased in association with fetal growth restriction. STUDY DESIGN: The expression of parathyroid hormone-related protein was examined in intrauterine tissues from women with idiopathic fetal growth restriction with preterm (n = 8-10) and term (n = 8-10) gestations and from gestation-matched control subjects. The abundance and immunoreactive content of parathyroid hormone-related protein mess..

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