YPEL1 overexpression in early avian craniofacial mesenchyme causes mandibular dysmorphogenesis by up-regulating apoptosis
Tiong Yang Tan, Christopher T Gordon, Kerry A Miller, David J Amor, Peter G Farlie
DEVELOPMENTAL DYNAMICS | WILEY | Published : 2015
BACKGROUND: The YPEL (Yippee-like) gene family comprises five highly conserved members (YPEL1-5), but their biological function remains largely unknown. Early studies of YPEL1 function suggested that it plays a role in the development of structures derived from the pharyngeal arches. Human YPEL1 localises to distal chromosome 22q11.2 and copy number changes at this locus lead to diverse phenotypes that include facial dysmorphism, facial asymmetry, and palatal anomalies comprising the distal 22q11.2 deletion/duplication syndromes (OMIM 611867). We therefore investigated the role of chick YPEL1 in craniofacial development using ex vivo and in vivo approaches in the avian model. RESULTS: We fou..View full abstract
Awarded by Australian National Health and Medical Research Council
Grant sponsor: Australian National Health and Medical Research Council; Grant number: Medical Postgraduate Scholarship 437003; Grant number: 284522; Grant number: 491229.