Journal article

Organisation of the motor cortex differs between people with and without knee osteoarthritis

Camille J Shanahan, Paul W Hodges, Tim V Wrigley, Kim L Bennell, Michael J Farrell

ARTHRITIS RESEARCH & THERAPY | BIOMED CENTRAL LTD | Published : 2015

Abstract

INTRODUCTION: The aim of this study was to investigate possible differences in the organisation of the motor cortex in people with knee osteoarthritis (OA) and whether there is an association between cortical organisation and accuracy of a motor task. METHODS: fMRI data were collected while 11 participants with moderate/severe right knee OA (6 male, 69 ± 6 (mean ± SD) years) and seven asymptomatic controls (5 male, 64 ± 6 years) performed three visually guided, variable force, force matching motor tasks involving isolated isometric muscle contractions of: 1) quadriceps (knee), 2) tibialis anterior (ankle) and, 3) finger/thumb flexor (hand) muscles. fMRI data were used to map the loci of peak..

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Grants

Awarded by National Health and Medical Research Council (NHMRC) of Australia


Awarded by NHMRC


Funding Acknowledgements

The study was funded by a Program Grant (ID631717) from the National Health and Medical Research Council (NHMRC) of Australia. Paul Hodges (APP1002190) and Kim Bennell (APP1058440) are funded by Research Fellowships from the NHMRC. Written informed consent was obtained from the participant depicted in Fig. 1 for publication of their individual details and accompanying images in this manuscript. The consent form is held by the authors' institution and is available for review by the Editor-in-Chief.