Journal article
Longitudinal investigation of adenovirus 36 seropositivity and human obesity: The Cardiovascular Risk in Young Finns Study
MA Sabin, D Burgner, RL Atkinson, Z Pei-Lun Lee, CG Magnussen, M Cheung, M Kähönen, T Lehtimäki, E Jokinen, T Laitinen, N Hutri-Kähönen, JSA Viikari, M Juonala, OT Raitakari
International Journal of Obesity | Published : 2015
DOI: 10.1038/ijo.2015.108
Abstract
Background/Objectives:Adenovirus-36 (Adv-36) infection is associated with exaggerated adipogenesis in cell culture and the development of obesity in animal models and humans, but a causal relationship remains unproven. Our objective was to determine whether serological evidence of Adv-36 infection in childhood and/or adulthood is associated with adult obesity.Subjects/Methods:Paired plasma concentrations of Adv-36 antibodies were measured by a novel enzyme-linked immunosorbent assay in a subgroup (n=449) of the Cardiovascular Risk in Young Finns Study in childhood (mean age 11.9 years) and adulthood (mean age 41.3 years). The study group included (1) individuals who had maintained normal-wei..
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Awarded by Tampereen Tuberkuloosisäätiö
Funding Acknowledgements
The Cardiovascular Risk in Young Finns Study has been financially supported by the Academy of Finland: Grants 134309 (Eye), 126925, 121584, 124282, 129378 (Salve), 117787 (Gendi) and 41071 (Skidi), the Social Insurance Institution of Finland, Kuopio, Tampere, and Turku University Hospital Medical Funds (9N035), Juho Vainio Foundation, Yrjo Jahnsson Foundation (Terho L), Paavo Nurmi Foundation, Finnish Foundation of Cardiovascular Research and Finnish Cultural Foundation, Tampere Tuberculosis Foundation and Emil Aaltonen Foundation. Authors from the Murdoch Childrens Research Institute are supported by the Victorian Government's Operational Infrastructure Support Program. MAS is supported through a National Health and Medical Research Council Health Professional Training Fellowship (APP1012201). CGM is supported through a National Health and Medical Research Council Early Career Fellowship (APP1037559). Funding for the Adv-36 assays was provided through an internal grant awarded by the Murdoch Childrens Research Institute (MCRI).