Common Sequence Variation in the VEGFC Gene Is Associated with Diabetic Retinopathy and Diabetic Macular Edema

G Kaidonis; KP Burdon; MC Gillies; S Abhary; RW Essex; JH Chang; B Pal; M Pefkianaki; M Daniell; S Lake; N Petrovsky; AW Hewitt; A Jenkins; EL Lamoureux; JM Gleadle; JE Craig

Journal article

Common Sequence Variation in the VEGFC Gene Is Associated with Diabetic Retinopathy and Diabetic Macular Edema

G Kaidonis, KP Burdon, MC Gillies, S Abhary, RW Essex, JH Chang, B Pal, M Pefkianaki, M Daniell, S Lake, N Petrovsky, AW Hewitt, A Jenkins, EL Lamoureux, JM Gleadle, JE Craig

Ophthalmology | ELSEVIER SCIENCE INC | Published : 2015

DOI: 10.1016/j.ophtha.2015.05.004

Abstract

Purpose To investigate associations between single nucleotide polymorphisms (SNPs) in the VEGFC gene and the development of diabetic retinopathy (DR) in white patients with type 1 diabetes mellitus (T1DM) or type 2 diabetes mellitus (T2DM). Design Cross-sectional, case control study. Participants White patients with T1DM or T2DM (n = 2899) were recruited from ophthalmology and endocrine clinics in Australia and the United Kingdom. Patients with T2DM were required to have diabetes mellitus (DM) for at least 5 years and be receiving oral hypoglycemic treatment or insulin. Methods Participants were categorized according to their worst-ever DR grading, as having "no DR" (no history of nonprolife..

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