Synthesis and evaluation of cationic norbornanes as peptidomimetic antibacterial agents
Shane M Hickey, Trent D Ashton, Simren K Khosa, Ryan N Robson, Jonathan M White, Jian Li, Roger L Nation, Heidi Y Yu, Alysha G Elliott, Mark S Butler, Johnny X Huang, Matthew A Cooper, Frederick M Pfeffer
Organic & Biomolecular Chemistry | ROYAL SOC CHEMISTRY | Published : 2015
Related Projects (1)
Awarded by ARC
Awarded by Australian Research Council through LIEF
Awarded by National Institute of Allergy and Infectious Diseases of the National Institutes of Health
F.M.P., S.M.H., S.K.K., R.N.R. & T.D.A. thank the ARC (DP140100227) and the Strategic Research Centre for Chemistry and Biotechnology (Deakin University) for financial support and a top-up scholarship for S.M.H. The authors would also like to thank Dr Damien Callahan for his assistance with the collection of HRMS and the Australian Research Council for funding Deakin University's Nuclear Magnetic Resonance Facility through LIEF grant LE110100141. J.L. & R.L.N. are supported by a research grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health (R01 AI098771). J.L. is an Australian NHMRC Senior Research Fellow, while M.A.C. is an Australian NHMRC Principal Research Fellow. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute of Allergy and Infectious Diseases or the National Institutes of Health. The MIC screening was done in collaboration with CO-ADD (Community for Open Antimicrobial Drug Discovery, co-add.org) and we thank David L. Paterson (UQCCR, University of Queensland) for his kind donation of clinical Gram-positive isolates used for testing.