Journal article

Associations of hippocampal metabolism and regional brain grey matter in neuroleptic-naive ultra-high-risk subjects and first-episode schizophrenia

Igor Nenadic, Raka Maitra, Soumyajit Basu, Maren Dietzek, Nils Schoenfeld, Carsten Lorenz, Alexander Gussew, G Paul Amminger, Patrick McGorry, Juergen R Reichenbach, Heinrich Sauer, Christian Gaser, Stefan Smesny

EUROPEAN NEUROPSYCHOPHARMACOLOGY | ELSEVIER SCIENCE BV | Published : 2015

Abstract

Hippocampal pathology has been shown to be central to the pathophysiology of schizophrenia and a putative risk marker for developing psychosis. We applied both (1)H MRS (proton magnetic resonance spectroscopy) at 3Tesla and voxel-based morphometry (VBM) of high-resolution brain structural images in order to study the association of the metabolites glutamate (Glu) and N-acetyl-aspartate (NAA) in the hippocampus with whole-brain morphometry in 31 persons at ultra-high-risk for psychosis (UHR), 18 first-episode schizophrenia patients (Sz), and 42 healthy controls (all subjects being neuroleptic-naïve). Significantly diverging associations emerged for UHR subjects hippocampal glutamate showed po..

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