Journal article

Striatal Atrophy in the Behavioural Variant of Frontotemporal Dementia: Correlation with Diagnosis, Negative Symptoms and Disease Severity

Matthew D Macfarlane, David Jakabek, Mark Walterfang, Susanna Vestberg, Dennis Velakoulis, Fiona A Wilkes, Christer Nilsson, Danielle van Westen, Jeffrey CL Looi, Alexander Frizell Santillo

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

INTRODUCTION: Behavioural variant frontotemporal dementia (bvFTD) is associated with changes in dorsal striatal parts of the basal ganglia (caudate nucleus and putamen), related to dysfunction in the cortico-striato-thalamic circuits which help mediate executive and motor functions. We aimed to determine whether the size and shape of striatal structures correlated with diagnosis of bvFTD, and measures of clinical severity, behaviour and cognition. MATERIALS AND METHODS: Magnetic resonance imaging scans from 28 patients with bvFTD and 26 healthy controls were manually traced using image analysis software (ITK-SNAP). The resulting 3-D objects underwent volumetric analysis and shape analysis, t..

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Grants

Funding Acknowledgements

JCLL self-funded travel costs and computer infrastructure to coordinate research in Australia and Sweden. The LUPROFS study received funding from The Swedish Alzheimer foundation, Thureus foundation, and benefited from the regional agreement on medical training and clinical research (ALF) between the Skane Regional Council and Lund University. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.