Journal article
Anthropometry and head and neck cancer: A pooled analysis of cohort data
MM Gaudet, CM Kitahara, CC Newton, L Bernstein, P Reynolds, E Weiderpass, AR Kreimer, G Yang, HO Adami, MC Alavanja, LE Beane Freeman, H Boeing, J Buring, A Chaturvedi, Y Chen, AA D'Aloisio, M Freedman, YT Gao, JM Gaziano, GG Giles Show all
International Journal of Epidemiology | Published : 2015
DOI: 10.1093/ije/dyv059
Abstract
Background: Associations between anthropometry and head and neck cancer (HNC) risk are inconsistent. We aimed to evaluate these associations while minimizing biases found in previous studies. Methods: We pooled data from 1 941 300 participants, including 3760 cases, in 20 cohort studies and used multivariable-adjusted Cox proportional hazard regression models to estimate hazard ratios (HR) and 95% confidence intervals (CI) for the association of anthropometric measures with HNC risk overall and stratified by smoking status. Results: Greater waist circumference (per 5cm: HR = 1.04, 95% CI 1.03-1.05, P-value for trend = < 0.0001) and waist-to-hip ratio (per 0.1 unit: HR = 1.07, 95% CI 1.05-1.0..
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Awarded by National Cancer Institute
Funding Acknowledgements
This work was supported in part by the American Cancer Society and the Intramural Research Program of the National Cancer Institute, National Institutes of Health, the National Institute of Environmental Health Sciences (Z01-ES049030) and National Cancer Institute (Z01-CP010119). Funding and acknowledgement information for each of the individual cohorts is available in the Appendix (available as Supplementary data at IJE online).