Pre-pregnancy maternal overweight and obesity increase the risk for affective disorders in offspring
M Robinson, SR Zubrick, CE Pennell, RJ Van Lieshout, P Jacoby, LJ Beilin, TA Mori, FJ Stanley, JP Newnham, WH Oddy
JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE | CAMBRIDGE UNIV PRESS | Published : 2013
Maternal pre-pregnancy obesity has been linked with an increased risk for negative emotionality and inattentiveness in offspring in early childhood. The aim of this study was to examine the association between maternal pre-pregnancy body mass index (BMI) and the development of affective problems (dysthymic disorder, major depressive disorder) throughout childhood and adolescence. In the Western Australian Pregnancy Cohort (Raine) Study, 2900 women provided data on their pre-pregnancy weight, and height measurements were taken at 18 weeks of gestation. BMI was calculated and categorized using standardized methods. Live-born children (n = 2868) were followed up at ages 5, 8, 10, 14 and 17 year..View full abstract
The authors acknowledge the core funding and support of the Raine Medical Research Foundation, The University of Western Australia (UWA), the National Health and Medical Research Council of Australia (NHMRC), the; Telethon Institute for Child Health Research, the; Telstra Foundation, the Western Australian Health Promotion Foundation, the UWA Faculty of Medicine, Dentistry and Health Science, the Women and Infants Research Foundation, Australian Health Management and the National Heart Foundation of Australia/Beyond Blue. Dr Robinson is funded by Australian Rotary Health and Qantas. The authors are extremely grateful to all the families who took part in this study and the Raine Study team, which includes data collectors, cohort managers, data managers, clerical staff, research scientists and volunteers.