Abnormal right ventricular relaxation in pulmonary hypertension
Stuart D Murch, Andre La Gerche, Timothy J Roberts, David L Prior, Andrew I MacIsaac, Andrew T Burns
Pulmonary Circulation | SAGE PUBLICATIONS INC | Published : 2015
Left ventricular diastolic dysfunction is a well-described complication of systemic hypertension. However, less is known regarding the effect of chronic pressure overload on right ventricular (RV) diastolic function. We hypothesized that pulmonary hypertension (PHT) is associated with abnormal RV early relaxation and that this would be best shown by invasive pressure measurement. Twenty-five patients undergoing right heart catheterization for investigation of breathlessness and/or suspected PHT were studied. In addition to standard measurements, RV pressure was sampled with a high-fidelity micromanometer, and RV pressure/time curves were analyzed. Patients were divided into a PHT group and a..View full abstract
This study was supported by a grant from Actelion Pharmaceuticals.