Different Topographic Response Between Mild to Moderate and Advanced Keratoconus After Accelerated Collagen Cross-linking

Abstract

PURPOSE: To evaluate the clinical and topographic effects after accelerated corneal collagen cross-linking (CXL) in keratoconus. METHODS: This was a prospective interventional study in 25 eyes of 24 Asian patients with keratoconus, where 10 eyes in group 1 had mild to moderate keratoconus with the steepest keratometry reading (Kmax) < 58 diopters (D), and 15 eyes in group 2 had advanced keratoconus with Kmax ≥ 58.0 D. The patients underwent accelerated CXL with 18 W/cm UV-A light for 5 minutes. Clinical and topographic parameters were obtained before and 1 year after treatment. RESULTS: Overall, spectacle-corrected distance visual acuity, refraction, average keratometry readings, Kmax, anter..