Generation of adaptive immune responses following influenza virus challenge is not compromised by pre-treatment with the TLR-2 agonist Pam(2)Cys
Edin Jessica Mifsud, Amabel CL Tan, Lorena Elizabeth Brown, Brendon Yew Loong Chua, David C Jackson
FRONTIERS IN IMMUNOLOGY | FRONTIERS MEDIA SA | Published : 2015
Immunostimulatory agents provide a new category of anti-microbial agents that activate the host's innate immune system allowing control of viral and/or bacterial infections. The TLR-2 agonist PEG-Pam2Cys has been shown to mediate potent anti-viral activity against influenza viruses when administered prophylactically (1). Here, we demonstrate that the treatment of mice with PEG-Pam2Cys does not compromise their ability to generate adaptive immune responses following subsequent challenge with influenza virus. The antibody induced in mice pre-treated with Pam2Cys possessed hemagglutination-inhibiting activities and the CD8(+) T-cell responses that were elicited provided protection against heter..View full abstract
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Awarded by National Health and Medical Research Council of Australia
This work was supported by project grant APP 1063209 and program grant APP1071916 from the National Health and Medical Research Council of Australia. DCJ is supported by a Research Fellowship from the NH&MRC. We would like to thank Dr. Weiguang Zeng for technical assistance.