Journal article

Assessment of the relationship between hypoglycaemia awareness and autonomic function following islet cell/pancreas transplantation

Jordan T Kamel, David J Goodman, Kathy Howe, Mark J Cook, Glenn M Ward, Leslie J Roberts

DIABETES-METABOLISM RESEARCH AND REVIEWS | WILEY | Published : 2015

Abstract

BACKGROUND: This study assesses the autonomic function of patients who have regained awareness of hypoglycaemia following islet cell or whole pancreas transplant. METHODS: Five patients with type 1 diabetes and either islet cell (four patients) or whole pancreas (one patient) transplant were assessed. These patients were age-matched and gender-matched to five patients with type 1 diabetes without transplant and preserved hypoglycaemia awareness and five healthy control participants without diabetes. All participants underwent (i) a battery of five cardiovascular autonomic function tests, (ii) quantitative sudomotor axonal reflex testing, and (iii) sympathetic skin response testing. RESULTS: ..

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