Journal article

Increased segregation of brain networks in focal epilepsy: An fMRI graph theory finding

Mangor Pedersen, Amir H Omidvarnia, Jennifer M Walz, Graeme D Jackson



Focal epilepsy is conceived of as activating local areas of the brain as well as engaging regional brain networks. Graph theory represents a powerful quantitative framework for investigation of brain networks. Here we investigate whether functional network changes are present in extratemporal focal epilepsy. Task-free functional magnetic resonance imaging data from 15 subjects with extratemporal epilepsy and 26 age and gender matched healthy controls were used for analysis. Local network properties were calculated using local efficiency, clustering coefficient and modularity metrics. Global network properties were assessed with global efficiency and betweenness centrality metrics. Cost-effic..

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Awarded by National Health and Medical Research Council (NHMRC) of Australia

Awarded by NHMRC practitioner's fellowship

Funding Acknowledgements

We acknowledge Evan Curwood for methodological guidance and Mira Semmelroch for assistance with the patient data. This study was supported by the National Health and Medical Research Council (NHMRC) of Australia (grant no. 628952). The Florey Institute of Neuroscience and Mental Health acknowledges the strong support from the Victorian Government and in particular the funding from the Operational Infrastructure Support Grant. G Jackson is supported by an NHMRC practitioner's fellowship (1060312). G Jackson has received honouraria from UCB, and royalties from Elsevier for Magnetic Resonance in Epilepsy 2nd ed. M Pedersen is supported by the University of Melbourne scholarships (MIRS & MIFRS).