Journal article

The role of epigenetic change in autism spectrum disorders

Yuk Jing Loke, Anthony John Hannan, Jeffrey Mark Craig

FRONTIERS IN NEUROLOGY | FRONTIERS MEDIA SA | Published : 2015

Abstract

Autism spectrum disorders (ASD) are a heterogeneous group of neurodevelopmental disorders characterized by problems with social communication, social interaction, and repetitive or restricted behaviors. ASD are comorbid with other disorders including attention deficit hyperactivity disorder, epilepsy, Rett syndrome, and Fragile X syndrome. Neither the genetic nor the environmental components have been characterized well enough to aid diagnosis or treatment of non-syndromic ASD. However, genome-wide association studies have amassed evidence suggesting involvement of hundreds of genes and a variety of associated genetic pathways. Recently, investigators have turned to epigenetics, a prime medi..

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Grants

Awarded by Australian National Health and Medical Research Council


Awarded by Financial Markets Foundation for Children


Funding Acknowledgements

This work was supported by grants from the Australian National Health and Medical Research Council (grant numbers 437015, 607358); the Financial Markets Foundation for Children (grant number 032-2007). JC and YL are also grateful to past support from the MCRI, which is supported in part by the Victorian Government's Operational Infrastructure Support Program. We thank Katrina Williams for her useful comments on the manuscript and the two anonymous reviewers for their constructive comments.