Gas-phase studies of metal catalyzed decarboxylative cross-coupling reactions of esters
Richard AJ O'Hair
PURE AND APPLIED CHEMISTRY | WALTER DE GRUYTER GMBH | Published : 2015
Metal-catalyzed decarboxylative coupling reactions of esters offer new opportunities for formation of C-C bonds with CO2 as the only coproduct. Here I provide an overview of: key solution phase literature; thermochemical considerations for decarboxylation of esters and thermolysis of esters in the absence of a metal catalyst. Results from my laboratory on the use of multistage ion trap mass spectrometry experiments and DFT calculations to probe the gas-phase metal catalyzed decarboxylative cross-coupling reactions of allyl acetate and related esters are then reviewed. These studies have explored the role of the metal carboxylate complex in the gas phase decarboxylative coupling of allyl acet..View full abstract
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Awarded by ARC through ARC CoE program
I thank: the ARC for financial support via grant DP110103844 and through the ARC CoE program; all the students, post-doctoral fellows and collaborators involved in helping develop a mechanistic understanding of metal-mediated decarboxylation in the gas-phase, especially Dr George Khairallah.