Calculating radiotherapy margins based on Bayesian modelling of patient specific random errors
A Herschtal, L te Marvelde, K Mengersen, Z Hosseinifard, F Foroudi, T Devereux, D Pham, D Ball, PB Greer, P Pichler, T Eade, A Kneebone, L Bell, H Caine, B Hindson, T Kron
PHYSICS IN MEDICINE AND BIOLOGY | IOP PUBLISHING LTD | Published : 2015
Collected real-life clinical target volume (CTV) displacement data show that some patients undergoing external beam radiotherapy (EBRT) demonstrate significantly more fraction-to-fraction variability in their displacement ('random error') than others. This contrasts with the common assumption made by historical recipes for margin estimation for EBRT, that the random error is constant across patients. In this work we present statistical models of CTV displacements in which random errors are characterised by an inverse gamma (IG) distribution in order to assess the impact of random error variability on CTV-to-PTV margin widths, for eight real world patient cohorts from four institutions, and f..View full abstract
Awarded by Australian Government National Health and Medical Research Council (NHMRC)
This work was supported by an Australian Government National Health and Medical Research Council (NHMRC) funding grant, no. 1023031.