Journal article

Breast Tissue Composition and Immunophenotype and Its Relationship with Mammographic Density in Women at High Risk of Breast Cancer

Jia-Min B Pang, David J Byrne, Elena A Takano, Nicholas Jene, Lara Petelin, Joanne McKinley, Catherine Poliness, Christobel Saunders, Donna Taylor, Gillian Mitchell, Stephen B Fox

PLoS One | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

AIM: To investigate the cellular and immunophenotypic basis of mammographic density in women at high risk of breast cancer. METHODS: Mammograms and targeted breast biopsies were accrued from 24 women at high risk of breast cancer. Mammographic density was classified into Wolfe categories and ranked by increasing density. The histological composition and immunophenotypic profile were quantified from digitized haematoxylin and eosin-stained and immunohistochemically-stained (ERα, ERβ, PgR, HER2, Ki-67, and CD31) slides and correlated to mammographic density. RESULTS: Increasing mammographic density was significantly correlated with increased fibrous stroma proportion (rs (22) = 0.5226, p = 0.0..

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Grants

Awarded by National Health and Medical Research Council, Australia


Funding Acknowledgements

This work was supported by funding to GM, SF, CS and DT from National Health and Medical Research Council, Australia, grant number 509302. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.