OS046. Genome-wide association scans identify novel maternalsusceptibility loci for preeclampsia.

M Johnson; S Brennecke; A-C Iversen; C East; G Olsen; J Kent; T Dyer; J Said; L Roten; L Abraham; J-A Zwart; B Winsvold; A Håberg; M Huentelman; H Krokan; M Gabrielsen; R Austgulen; J Blangero; E Moses

Journal article

OS046. Genome-wide association scans identify novel maternalsusceptibility loci for preeclampsia.

M Johnson, S Brennecke, A-C Iversen, C East, G Olsen, J Kent, T Dyer, J Said, L Roten, L Abraham, J-A Zwart, B Winsvold, A Håberg, M Huentelman, H Krokan, M Gabrielsen, R Austgulen, J Blangero, E Moses

Pregnancy Hypertension | Published : 2012

DOI: 10.1016/j.preghy.2012.04.047

Abstract

INTRODUCTION: We have successfully utilized a family-based study design to localize several positional candidate preeclampsia susceptibility genes to chromosomes 2q22(ACVR2A,LCT,LRP1B,RND3,GCA),5q (ERAP2) and 13q(TNFSF13B). We now report on our continued positional cloning efforts using an alternative genome-wide association (GWA) mapping strategy in large Caucasian case-control cohorts from Australia and Norway. OBJECTIVES: To identify maternal genetic risk loci for preeclampsia. METHODS: The unrelated Australian samples (545 cases,547 controls) were genotyped using Illumina BeadChip technology (700K loci) and have been analyzed using PLINK. All unrelated Norwegian samples were genotyped ac..

View full abstract