Journal article
Safety and Efficacy of Human Wharton's Jelly-Derived Mesenchymal Stem Cells Therapy for Retinal Degeneration
SN Leow, Chi D Luu, MH Hairul Nizam, PL Mok, R Ruhaslizan, HS Wong, Wan Haslina Wan Abdul Halim, MH Ng, BHI Ruszymah, SR Chowdhury, MLC Bastion, KY Then
PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015
Abstract
PURPOSE: To investigate the safety and efficacy of subretinal injection of human Wharton's Jelly-derived mesenchymal stem cells (hWJ-MSCs) on retinal structure and function in Royal College of Surgeons (RCS) rats. METHODS: RCS rats were divided into 2 groups: hWJ-MSCs treated group (n = 8) and placebo control group (n = 8). In the treatment group, hWJ-MSCs from healthy donors were injected into the subretinal space in one eye of each rat at day 21. Control group received saline injection of the same volume. Additional 3 animals were injected with nanogold-labelled stem cells for in vivo tracking of cells localisation using a micro-computed tomography (microCT). Retinal function was assessed ..
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Awarded by Universiti Kebangsaan Malaysia Industry University Research Incentive Grant
Funding Acknowledgements
Funding for this work came from Universiti Kebangsaan Malaysia Industry University Research Incentive Grant (Industri-2011-048). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The author who received funding is ML.