Journal article

Safety and Efficacy of Human Wharton's Jelly-Derived Mesenchymal Stem Cells Therapy for Retinal Degeneration

SN Leow, Chi D Luu, MH Hairul Nizam, PL Mok, R Ruhaslizan, HS Wong, Wan Haslina Wan Abdul Halim, MH Ng, BHI Ruszymah, SR Chowdhury, MLC Bastion, KY Then

PLOS ONE | PUBLIC LIBRARY SCIENCE | Published : 2015

Abstract

PURPOSE: To investigate the safety and efficacy of subretinal injection of human Wharton's Jelly-derived mesenchymal stem cells (hWJ-MSCs) on retinal structure and function in Royal College of Surgeons (RCS) rats. METHODS: RCS rats were divided into 2 groups: hWJ-MSCs treated group (n = 8) and placebo control group (n = 8). In the treatment group, hWJ-MSCs from healthy donors were injected into the subretinal space in one eye of each rat at day 21. Control group received saline injection of the same volume. Additional 3 animals were injected with nanogold-labelled stem cells for in vivo tracking of cells localisation using a micro-computed tomography (microCT). Retinal function was assessed ..

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University of Melbourne Researchers