Endovascular stent thrombectomy: the new standard of care for large vessel ischaemic stroke
Bruce CV Campbell, Geoffrey A Donnan, Kennedy R Lees, Werner Hacke, Pooja Khatri, Michael D Hill, Mayank Goyal, Peter J Mitchell, Jeffrey L Saver, Hans-Christoph Diener, Stephen M Davis
The Lancet Neurology | ELSEVIER SCIENCE INC | Published : 2015
Awarded by National Health and Medical Research Council of Australia
Awarded by Alberta Innovates
BCVC reports research support from the National Health and Medical Research Council of Australia (grant 1043242, 1035688), Royal Australasian College of Physicians, Royal Melbourne Hospital Foundation, National Heart Foundation of Australia, National Stroke Foundation of Australia, and unrestricted grant funding for the EXTEND-IA trial to the Florey Institute of Neuroscience and Mental Health from Covidien (Medtronic). GAD reports grants from the Australian National Health and Medical Research Council, non-financial support from Boehringer Ingelheim, and has served on advisory boards for Boehringer Ingelheim, AstraZeneca, Bristol-Myers Squibb (BMS), and Merck Sharp & Dohme (MSD). KRL reports personal fees from Boehringer Ingelheim, Ever NeuroPharma, Hilicon, Nestle, American Heart Association, University of Lancaster (Lancaster, UK), Novartis, Fundacio Ictus, and Sanofi. WH reports personal fees from Covidien (Medtronic) and Boehringer Ingelheim, and grants from Boehringer Ingelheim. PK reports financial support to her institution for her research roles from Genentech (lead principal investigator of the PRISMS trial), Penumbra (neurology principal investigator of the THERAPY trial), and Biogen (data safety and monitoring board member). MDH reports unrestricted grant funding for the ESCAPE trial to the University of Calgary (Calgary, AB, Canada) from Covidien (Medtronic), and grant or in-kind support to the University of Calgary from Alberta Innovates Health Solutions, Heart and Stroke Foundation, Hotchkiss Brain Institute, Canadian Stroke Prevention Intervention Network, Calgary Stroke Program, and Alberta Health Services. MDH reports personal fees from Merck and non-financial support from Hoffmann-La Roche Canada Ltd, outside the submitted work. MDH has a patent on systems and methods for assisting in decision making and triaging for acute stroke patients, pending to the US Patent office (number 62/086,077) and owns stock in Calgary Scientific Incorporated. MG reports grants and personal fees from Covidien (Medtronic). MG has a patent on systems and methods for diagnosis of stroke (PCT/CA2013/000761) licensed to GE Healthcare. JLS is an employee of the University of California (Los Angeles, CA, USA), which receives funding for JLS's services as a scientific consultant for trial design and completion to Covidien (Medtronic), Stryker, BrainsGate, Pfizer, Boehringer Ingelheim, and St Jude Medical. JLS has served as an unpaid site investigator in multicentre trials run by Lundbeck for which the University of California Regents received payments on the basis of clinical trial contracts for the number of participants enrolled. JLS is an unpaid consultant to Genentech, advising on the design and undertaking of the PRISMS trial, for which JLS and the University of California did not receive any payments. The University of California has patent rights in retrieval devices for stroke. H-CD reports personal fees from Covidien and has received honoraria for participation in clinical trials, contribution to advisory boards, or oral presentations from Abbott, Allergan, AstraZeneca, Bayer Vital, BMS, Boehringer Ingelheim, CoAxia, Corimmun, Covidien, Daiichi-Sankyo, D-Pharm, Fresenius, GlaxoSmithKline (GSK), Janssen-Cilag, Johnson & Johnson, Knoll, Eli Lilly, MSD, Medtronic, MindFrame, Neurobiological Technologies, Novartis, Novo-Nordisk, Paion, Parke-Davis, Pfizer, Sanofi-Aventis, Schering-Plough, Servier, Solvay, St Jude, Syngis, Talecris, Thrombogenics, WebMD Global, Wyeth, and Yamanouchi.H-CD reports financial support for research projects from AstraZeneca, GSK, Boehringer Ingelheim, Lundbeck, Novartis, Janssen-Cilag, Sanofi-Aventis, Syngis, and Talecris. H-CD's centre (Department of Neurology, University Duisburg-Essen, Germany) has received research grants from the German Research Council, German Ministry of Education and Research, European Union, National Institute of Health, Bertelsmann Foundation, and Heinz-Nixdorf Foundation. SMD reports lecture fees from Covidien (Medtronic). PJM declares no competing interests.