Journal article

Model Membrane and Cell Studies of Antimicrobial Activity of Melittin Analogues

Elaheh Jamasbi, Anna Mularski, Frances Separovic

CURRENT TOPICS IN MEDICINAL CHEMISTRY | BENTHAM SCIENCE PUBL LTD | Published : 2016

Abstract

Melittin is a 26 residue peptide and the major component of bee (Apis mellifera) venom. Although melittin has both anticancer and antimicrobial properties, utilization has been limited due to its high lytic activity against eukaryotic cells. The mechanism of this lytic activity remains unclear but several mechanisms have been proposed, including pore formation or a detergent like mechanism, which result in lysis of cell membranes. Several analogues of melittin have been synthesized to further understand the role of specific residues in its antimicrobial and lytic activity. Melittin analogues that have a proline residue substituted for an alanine, lysine or cysteine have been studied with bot..

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University of Melbourne Researchers