Model Membrane and Cell Studies of Antimicrobial Activity of Melittin Analogues
Elaheh Jamasbi, Anna Mularski, Frances Separovic
CURRENT TOPICS IN MEDICINAL CHEMISTRY | BENTHAM SCIENCE PUBL LTD | Published : 2016
Melittin is a 26 residue peptide and the major component of bee (Apis mellifera) venom. Although melittin has both anticancer and antimicrobial properties, utilization has been limited due to its high lytic activity against eukaryotic cells. The mechanism of this lytic activity remains unclear but several mechanisms have been proposed, including pore formation or a detergent like mechanism, which result in lysis of cell membranes. Several analogues of melittin have been synthesized to further understand the role of specific residues in its antimicrobial and lytic activity. Melittin analogues that have a proline residue substituted for an alanine, lysine or cysteine have been studied with bot..View full abstract
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Awarded by Australian Research Council
We acknowledge partial support of the study undertaken in the authors' laboratory by the Australian Research Council, DP140102127 to FS.