A Role for the Calcitonin Receptor to Limit Bone Loss During Lactation in Female Mice by Inhibiting Osteocytic Osteolysis
Michele V Clarke, Patricia K Russell, David M Findlay, Stephen Sastra, Paul H Anderson, Jarrod P Skinner, Gerald J Atkins, Jeffrey D Zajac, Rachel A Davey
ENDOCRINOLOGY | ENDOCRINE SOC | Published : 2015
During lactation, the large transfer of calcium from the mother to the milk is primarily sourced from the maternal skeleton. To determine whether the calcitonin receptor (CTR) plays a physiological role to protect the skeleton from excessive resorption during lactation, we assessed the maternal skeleton of global CTR knockout (CTRKO) and littermate control mice at the end of lactation (postnatal day 21). Micro-computed tomography analyses showed no effect on trabecular or cortical bone in the distal femur and L1 vertebra of maternal global CTR deletion at the end of lactation in global CTRKO mice compared with that in control mice. Bone resorption, as assessed by osteoclast number and activi..View full abstract
Awarded by National Health and Medical Research Council of Australia
This work was supported by the National Health and Medical Research Council of Australia (Project Grant APP1058189), the Austin Health Research Foundation, and a Les and Eva Erdi research grant.