Journal article
Semi-automated hippocampal segmentation in people with cognitive impairment using an age appropriate template for registration
B Merkel, C Steward, L Vivash, CB Malpas, P Phal, BA Moffat, KL Cox, KA Ellis, DJ Ames, EV Cyarto, MMY Lai, MJ Sharman, C Szoeke, CL Masters, NT Lautenschlager, P Desmond
Journal of Magnetic Resonance Imaging | WILEY | Published : 2015
DOI: 10.1002/jmri.24966
Abstract
Background To evaluate a new semi-automated segmentation method for calculating hippocampal volumes and to compare results with standard software tools in a cohort of people with subjective memory complaints (SMC) and mild cognitive impairment (MCI). Methods Data from 58 participants, 39 with SMC (17 male, 22 female, mean age 72.6) and 19 with MCI (6 male, 13 female, mean age 74.3), were analyzed. For each participant, T1-weighted images were acquired using an MPRAGE sequence on a 3 Tesla MRI system. Hippocampal volumes (left, right, and total) were calculated with a new, age appropriate registration template, based on older people and using the advanced software tool ANTs (Advanced Normaliz..
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Awarded by Science and Industry Endowment Fund
Funding Acknowledgements
[ "Contract grant sponsor: Australia's National Health and Medical Research Council; Contract grant number: 1005492.", "We are most grateful to all volunteers taking part in the study and to the research staff from following institutes in Melbourne, Victoria: the National Ageing Research Institute (NARI), the Mental Health Research institute (MHRI) and the Department of Radiology at the Royal Melbourne Hospital. N.L., P.D., K.C., D.A., C.S., K.E., P.P., and C.M. were funded by a project grant from Australia's National Health and Medical Research Council. Funding for the AIBL study is provided by the CSIRO Flagship Collaboration Fund and the Science and Industry Endowment Fund (SIEF) in partnership with Edith Cowan University (ECU), Mental Health Research institute (MHRI), Alzheimer's Australia (AA), National Ageing Research Institute (NARI), Austin Health, CogState Ltd., Hollywood Private Hospital, Sir Charles Gardner Hospital. The study also receives funding from the National Health and Medical Research Council, the Dementia Collaborative Research Centres program (DCRC2) and The McCusker Alzheimer's Research Foundation and Operational Infrastructure Support from the Government of Victoria." ]