Journal article
Sibling exposure and risk of juvenile idiopathic arthritis
J Miller, AL Ponsonby, A Pezic, A Kemp, SE Piper, JD Akikusa, RC Allen, JE Munro, JA Ellis
Arthritis and Rheumatology | Published : 2015
DOI: 10.1002/art.39129
Abstract
Objective Susceptibility to juvenile idiopathic arthritis (JIA) is presumed to be determined by both genes and environment. However, the environmental factors remain largely unknown. The hygiene hypothesis suggests that exposure to siblings, as a marker of exposure to microbes in early life, may protect against the development of later immune disorders. Some prior evidence suggests this may also be true for JIA. The present study was undertaken to test this hypothesis in detail. Methods We conducted a comprehensive analysis of the role of sibling exposure in JIA risk within the Childhood Arthritis Risk Factor Identification Study JIA case-hospital control sample (302 cases and 676 controls) ..
View full abstractGrants
Funding Acknowledgements
Supported by the Australian National Health and Medical Research Council (NHMRC), the Australian Research Council (ARC), Arthritis Australia, the Rebecca L. Cooper Foundation, the LEW Carty Charitable Fund, the ANZ Medical Research and Technologies in Victoria Fund, the Lynne Quayle Charitable Trust, The Victorian State Government Operational Infrastructure Support Program, and the Murdoch Childrens Research Institute. Dr. Ponsonby's work was supported by an NHMRC Senior Research Fellowship. Dr. Ellis' work was supported by an ARC Future Fellowship.