Journal article
Accelerated corpus callosum development in prematurity predicts improved outcome
DK Thompson, KJ Lee, L van Bijnen, A Leemans, L Pascoe, SE Scratch, J Cheong, GF Egan, TE Inder, LW Doyle, PJ Anderson
Human Brain Mapping | Published : 2015
DOI: 10.1002/hbm.22874
Abstract
Objectives: To determine: (1) whether corpus callosum (CC) size and microstructure at 7 years of age or their change from infancy to 7 years differed between very preterm (VP) and full-term (FT) children; (2) perinatal predictors of CC size and microstructure at 7 years; and (3) associations between CC measures at 7 years or trajectories from infancy to 7 years and neurodevelopmental outcomes. Experimental design: One hundred and thirty-six VP (gestational age [GA] <30 weeks and/or birth weight <1,250 g) and 33 FT children had usable magnetic resonance images at 7 years of age, and of these, 76 VP and 16 FT infants had usable data at term equivalent age. The CC was traced and divided into si..
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Awarded by National Institute of Child Health and Human Development
Funding Acknowledgements
Contract grant sponsor: Australia's National Health & Medical Research Council (Centre for Clinical Research Excellence; Contract grant number: 546519 to LD and PA; Project grants; Contract grant number: 237117 to LD, 491209 to PA, 400317 to GE; Senior Research Fellowship; Contract grant number: 628371 to PA; Early Career Fellowships; Contract grant number: 1012236 to DT, 1053787 to JC, 1053609 to KL); Contract grant sponsor: National Institutes of Health; Contract grant number: HD058056; Contract grant sponsor: Netherlands Organisation for Scientific Research (NWO) VIDI Grant; Contract grant number: 639.072.411 to AL; United Cerebral Palsy Foundation (USA), Leila Y. Mathers Charitable Foundation (USA), the Brown Foundation (USA), the Victorian Government's Operational Infrastructure Support Program, and The Royal Children's Hospital Foundation.