Osteoclast TGF-beta Receptor Signaling Induces Wnt1 Secretion and Couples Bone Resorption to Bone Formation
Megan M Weivoda, Ming Ruan, Larry Pederson, Christine Hachfeld, Rachel A Davey, Jeffrey D Zajac, Jennifer J Westendorf, Sundeep Khosla, Merry Jo Oursler
Journal of Bone and Mineral Research | WILEY-BLACKWELL | Published : 2016
Awarded by National Institutes of Health (NIH) National Institute on Aging (NIA)
Awarded by National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIAMS)
This work was supported by the National Institutes of Health (NIH) National Institute on Aging (NIA) P01 AG004875; National Institute of Arthritis, Musculoskeletal, and Skin Diseases (NIAMS) T32 AR056950 and F32 AR064679; and the Robert and Arlene Kogod Center on Aging Career Development Award. We thank Ms. Glenda Evans of the Mayo Clinic Bone Histomorphometry Lab for her assistance with mu CT analysis, Dr. Meghan McGee-Lawrence, PhD, for her assistance with reference point indentation, Ms. Maria Chiu, MS, and Dr. Julie McManus, PhD, for contributing to the development of the transgenic Ctsk promoter Cre Recombinase mice, and Dr. Harold L. Moses, MD, for generously providing Tgfbr2 ligand binding floxed mice. We also thank Dr. David G. Monroe for providing his TOPFlash luciferase plasmid.