Electrophysiological, Electroanatomical, and Structural Remodeling of the Atria as Consequences of Sustained Obesity
Rajiv Mahajan, Dennis H Lau, Anthony G Brooks, Nicholas J Shipp, Jim Manavis, John PM Wood, John W Finnie, Chrishan S Samuel, Simon G Royce, Darragh J Twomey, Shivshanker Thanigaimani, Jonathan M Kalman, Prashanthan Sanders
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY | ELSEVIER SCIENCE INC | Published : 2015
BACKGROUND: Obesity and atrial fibrillation (AF) are public health issues with significant consequences. OBJECTIVES: This study sought to delineate the development of global electrophysiological and structural substrate for AF in sustained obesity. METHODS: Ten sheep fed ad libitum calorie-dense diet to induce obesity over 36 weeks were maintained in this state for another 36 weeks; 10 lean sheep with carefully controlled weight served as controls. All sheep underwent electrophysiological and electroanatomic mapping; hemodynamic and imaging assessment (echocardiography and dual-energy x-ray absorptiometry); and histology and molecular evaluation. Evaluation included atrial voltage, conductio..View full abstract
Dr. Mahajan is supported by the Leo J. Mahar Lectureship from the University of Adelaide. Dr. Lau is supported by a postdoctoral fellowship from the National Health and Medical Research Council of Australia (NHMRC). Drs. Brooks and Sanders are supported by the National Heart Foundation of Australia. Dr. Samuel is supported by an NHMRC Senior Research Fellowship. Dr. Twomey is supported by the Leo J. Mahar Electrophysiology Scholarship from the University of Adelaide. Dr. Thanigaimani is supported by the Peter Hetzel Electrophysiology Scholarship from the University of Adelaide. Dr. Kalman is supported by a Practitioner Fellowship from the NHMRC; and has received research funding from St. Jude Medical, Biosense Webster, Medtronic, and Boston Scientific. Dr. Sanders is supported by a Practitioner Fellowship from the NHMRC; has served on the advisory boards of Biosense Webster, Medtronic, St. Jude Medical, Sanofi, and Merck, Sharpe and Dohme; has received lecture and/or consulting fees from Biosense Webster, Medtronic, St. Jude Medical, Boston Scientific, Merck, Sharpe and Dohme, Biotronik, and Sanofi; and has received research funding from Medtronic, St. Jude Medical, Boston Scientific, Biotronik, and Sorin. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose. Previously presented at the Annual Scientific Sessions of the Heart Rhythm Society, May 2012, Boston, Massachusetts, and published in abstract form ( Heart Rhythm 2012; 9: S185). Drs. Lau and Sanders contributed equally to this paper.