A Phase 1 exercise dose escalation study for stroke survivors with impaired walking
Wayne Dite, Zoe N Langford, Toby B Cumming, Leonid Churilov, Jannette M Blennerhassett, Julie Bernhardt
INTERNATIONAL JOURNAL OF STROKE | SAGE PUBLICATIONS LTD | Published : 2015
BACKGROUND: Targeted exercise and increased practice can improve the mobility of stroke survivors. However, many stroke survivors continue to have reduced physical work capacity and impaired walking, and experience frequent falls after participating in physical rehabilitation programs. AIM: In this Phase 1 study, we used a dose escalation method, common in pharmaceutical trials, to determine the maximum tolerable dose of multimodal exercise in community-dwelling stroke survivors with mobility impairment. METHODS: Stroke survivors 14-59 months poststroke participated in a 12-week (36 sessions) multimodal exercise program implemented using a cumulative 3 + 3 dose escalation design (featuring i..View full abstract
This project was funded through an Australian National Stroke Foundation Grant.