Journal article

A Phase 1 exercise dose escalation study for stroke survivors with impaired walking

Wayne Dite, Zoe N Langford, Toby B Cumming, Leonid Churilov, Jannette M Blennerhassett, Julie Bernhardt

INTERNATIONAL JOURNAL OF STROKE | SAGE PUBLICATIONS LTD | Published : 2015

Abstract

BACKGROUND: Targeted exercise and increased practice can improve the mobility of stroke survivors. However, many stroke survivors continue to have reduced physical work capacity and impaired walking, and experience frequent falls after participating in physical rehabilitation programs. AIM: In this Phase 1 study, we used a dose escalation method, common in pharmaceutical trials, to determine the maximum tolerable dose of multimodal exercise in community-dwelling stroke survivors with mobility impairment. METHODS: Stroke survivors 14-59 months poststroke participated in a 12-week (36 sessions) multimodal exercise program implemented using a cumulative 3 + 3 dose escalation design (featuring i..

View full abstract