ANXIOGENIC DRUG ADMINISTRATION AND ELEVATED PLUS-MAZE EXPOSURE IN RATS ACTIVATE POPULATIONS OF RELAXIN-3 NEURONS IN THE NUCLEUS INCERTUS AND SEROTONERGIC NEURONS IN THE DORSAL RAPHE NUCLEUS
AJ Lawther, ML Clissold, S Ma, S Kent, CA Lowry, AL Gundlach, MW Hale
NEUROSCIENCE | PERGAMON-ELSEVIER SCIENCE LTD | Published : 2015
Anxiety is a complex and adaptive emotional state controlled by a distributed and interconnected network of brain regions, and disruption of these networks is thought to give rise to the behavioral symptoms associated with anxiety disorders in humans. The dorsal raphe nucleus (DR), which contains the majority of forebrain-projecting serotonergic neurons, is implicated in the control of anxiety states and anxiety-related behavior via neuromodulatory effects on these networks. Relaxin-3 is the native neuropeptide ligand for the Gi/o-protein-coupled receptor, RXFP3, and is primarily expressed in the nucleus incertus (NI), a tegmental region immediately caudal to the DR. RXFP3 activation has bee..View full abstract
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Awarded by National Health and Medical Research Council (NHMRC) of Australia
This research was supported by Grants the National Health and Medical Research Council (NHMRC) of Australia (1005985, 1005988 and 1067522, A.L.G.); the Besen Family Foundation (A.L.G.); and by the Victorian Government Operational Infrastructure Support Program. A.J.L. is the recipient of an Australian Postgraduate Scholarship (APA).