Journal article

Maternal vitamin D supplementation during pregnancy prevents vitamin D deficiency in the newborn: an open-label randomized controlled trial

CP Rodda, JE Benson, AJ Vincent, CL Whitehead, A Polykov, B Vollenhoven



OBJECTIVE: To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency. DESIGN: Open-label randomized controlled trial. SETTING: Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic. PARTICIPANTS: Seventy-eight women with singleton pregnancies with vitamin D deficiency/insufficiency (serum 25-OH Vit D < 75 nmol/l) at their first antenatal appointment at 12-16-week gestation were recruited. INTERVENTION: Participants were randomized to vitamin D supplementation (2000-4000 IU cholecalciferol) orally daily until delivery or no supplementation. MAIN OUTCOME MEASURES: The primary outcome was..

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Funding Acknowledgements

J.E. Benson was a recipient of the Luke Proposch Perinatal Research Scholarship from the Australian and New Zealand College of Obstetrics and Gynaecology Research Foundation enabling her to undertake this research. We would like to thank our study participants, Sandra Yeowart and the staff of the Monash Health Antenatal Clinic and Delivery Suite, Clayton campus, Monash Health Biochemistry Department for the 25 OH Vitamin D assays, and Professor Euan Wallace, Head Director of Obstetrics, Monash Health for his clinical advice.